Miriam O'Callaghan will stand in on his behalf.
Ryan Tubridy will not be presenting tonight's Late Late show because he has a persistent cough.
The host has decided to stay away as a precaution, and Miriam O'Callaghan will stand in on his behalf.
The show will honour frontline workers and feature League of Ireland footballer Lee Duffy who was hospitalised with the virus.
Hozier will launch an emergency appeal for the ISPCC, and Brendan O'Carroll will join the show via video link from Florida.
Brian O'Driscoll and Mícheál Ó Muircheartaigh will also feature tonight.