The show is one of the most popular in US television history
One of the longest running sitcoms in US history will air it's final episode in 2019.
It's been confirmed The Big Bang Theory's 12th season will also be it's last and will conclude in May next year.
Set in Pasadena, California, the series originally focused on two physicists and their aspiring actress neighbour.
The Big Bang Theory has attracted more than 18 million viewers every year since its sixth season aired in 2012.
It reportedly averaged 18.6 million viewers per episode in its 11th season, more than any other show on US television.
The production teams and CBS said in a joint statement they were "forever grateful" to the fans.
"We, along with the cast, writers and crew, are extremely appreciative of the show's success and aim to deliver a final season, and series finale, that will bring The Big Bang Theory to an epic creative close," it read.
The series has won seven Emmys from 46 nominations, including four Outstanding Lead Actor wins for Jim Parsons, who plays the socially inept character Sheldon Cooper.
